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KMID : 0603520030080010045
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Journal of Korean Association of Cancer Prevention
2003 Volume.8 No. 1 p.45 ~ p.52
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Effect of Selenium on Chemoprevention and Metastasis
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Chung An-Sik
Yoon Sang-Oh
Jung U-Hee
Park Jong-Min
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Abstract
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Selenium (Se), an essential trace element for anima1s, has been proven to maintain good health and shown to prevent several diseases. White muscle disease and muscular dystrophy have been identified by Se deficient syndrome since l950. This can be explained by antioxidant characters of selenium as glutathione peroxidase, thioredoxin reductase, phospholipid hydroperoxidase and other selenoproteins such as selenoprotein W and P. Selenium is also needed for the proper functioning of the immune system, and appears to be a key nutrient in counteracting the development of virulence and inhibiting HIV progression to AIDS. an elevated selenium intake may be associated with reduced risk. Se supplementation has been dramatically reduced cancer incidence, such as prostate, colon, lung and pancreatic cancers in human. It has been known that the inhibition of cancer cell proliferation induce cell cycle arrest and apoptosis. We demonstrated that treatment with selenomethylselenocysteine induced apoptosis in HL-60 cells via increased reactive oxygen species. Apoptosis was detected by sequencial events, mitochondrial membrane potential, cytochrome C release, and caspase activation. Treatment with lower selenite (1~3μM) in HT1080 cells inhibited tumor cell invasion by abolishng the activation of matrix metal1oproteinse-2 and -9 and urokinase type plasminogen activation and reduced expression their mRNA, which were related to reduce activation of transcriptional factor such as AP-l and NF-kB. These results suggest that moderate concentration of Se induces apoptosis, and lower concentration is effective to inhibit tumor invasion and further possible metastasis.
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KEYWORD
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Selenium (Se), HL-60 cells, Apoptosis
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